三氟乙醛缩半乙醇化学性质沸点:104-105°C/745mmHg(lit.)密度:1.221g/mLat25°C(lit.)折射率:n20/D1.342(lit.)闪点:97°F储存条件:2-8°C溶解度:Chloroform,EthylAcetate酸度系数(pKa):10.57±0.20(Predicted)形态:Liquid比重:1.2Chemicalbook41颜色:ClearcolorlessBRN:906797CAS数据库:433-27-2(CASDataBaseReference)NIST化学物质信息:Ethanol,1-ethoxy-2,2,2-trifluoro-(433-27-2)EPA化学物质信息:Ethanol,1-ethoxy-2,2,2-trifluoro-(433-27-2)
*The following content is generated by AI and is for reference only.
Trifluoroacetaldehyde ethyl hemiacetal is a specialized organofluorine compound widely utilized in the fine chemical and pharmaceutical industries. With the molecular formula C4H7F3O2 and CAS Registry Number 1569-86-0, this colorless liquid serves as a crucial intermediate for synthesizing complex fluorinated molecules. The presence of the trifluoromethyl group imparts unique physicochemical properties, including enhanced lipophilicity and metabolic stability, which are highly desirable in modern drug discovery.
Primarily employed as a building block, this reagent facilitates the introduction of the CF3CH(OEt)- moiety into various organic scaffolds. It plays an indispensable role in the production of agrochemicals, particularly herbicides and fungicides that require specific fluorination patterns to optimize efficacy and environmental persistence. In the pharmaceutical sector, it is used to construct bioisosteres of aldehydes or ketones, aiding in the development of novel therapeutics for treating cardiovascular diseases, oncology conditions, and central nervous system disorders. The hemiacetal structure offers superior stability compared to free trifluoroacetaldehyde, making it easier to handle, store, and transport under standard laboratory and industrial conditions without rapid decomposition.
Synthetically, it acts as a versatile precursor in nucleophilic addition reactions, allowing chemists to generate diverse derivatives such as enamines, acetals, and heterocyclic compounds. Its reactivity can be precisely tuned through catalytic systems, enabling high selectivity in multi-step synthesis sequences. Furthermore, researchers utilize this compound to study reaction mechanisms involving fluorinated carbonyl species, contributing to broader advancements in organofluorine chemistry. Due to its volatility and potential irritant properties, strict safety protocols are recommended during handling, including the use of appropriate personal protective equipment and ventilation systems. As the demand for fluorinated materials grows across technology and medicine, Trifluoroacetaldehyde ethyl hemiacetal remains a pivotal reagent bridging fundamental research and commercial application, driving innovation in creating next-generation functional materials with tailored performance characteristics.
(All Rights Reserved)
![8-Oxa-1,3-diazaspiro[4.5]decane-2,4-dione](https://eimg.pharmasources.com/image/product/20250403/60fa7223d5a34f24138486ceea0ffb15jpg)
![8,16-Diazadispiro[6.1.6.2]heptadecan-17-one](https://eimg.pharmasources.com/image/product/20250403/ca91cba8b87e53fc879f8d8764873a40jpg)
![6,8-Dioxo-5,7-diazaspiro[3.4]octane-2-carboxylic acid](https://eimg.pharmasources.com/image/product/20250403/02effeb5a7639bc84ff1f3add3c0c64fjpg)
