恩氯米芬柠檬酸盐化学性质熔点:143-145°C储存条件:AmberVial,-20°CFreezer溶解度:DMSO(Slightly),EthylAcetate(Slightly,HeaChemicalbookted,Sonicated)形态:Solid颜色:WhitetoOff-White稳定性:LightSensitiveInChIKey:PYTMYKVIJXPNBD-BTKVJIOYSA-N
*The following content is generated by AI and is for reference only.
Trans-Clomiphene Citrate is a stereoisomer of the widely used fertility medication Clomiphene Citrate, distinguished by its specific trans-configuration which offers unique pharmacological properties. With the Chemical Abstracts Service (CAS) number 56147-28-9, this compound possesses the molecular formula C₂₆H₂₈ClNO and functions primarily as a Selective Estrogen Receptor Modulator (SERM). Unlike its cis-counterpart, the trans-isomer demonstrates distinct binding affinities and metabolic pathways, making it an area of significant interest in both reproductive endocrinology and emerging therapeutic research.
The primary application of Trans-Clomiphene Citrate lies in the management of female infertility caused by ovulatory dysfunction. By competitively blocking estrogen receptors in the hypothalamus, it inhibits negative feedback mechanisms, thereby stimulating the release of gonadotropin-releasing hormone (GnRH). This cascade triggers increased secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland, promoting follicular development and subsequent ovulation. While standard Clomiphene Citrate contains a mixture of cis and trans isomers, isolating the trans-form allows for more precise dosing and potentially reduced side effects associated with the other isomer.
Beyond traditional fertility treatments, researchers are investigating the potential of this molecule in male hypogonadism to stimulate testosterone production without the adverse effects of exogenous testosterone therapy. Its ability to modulate estrogen signaling makes it valuable for maintaining hormonal balance in various clinical scenarios. The citrate salt form ensures high solubility and stability, facilitating effective oral administration. However, usage requires strict medical supervision due to potential side effects such as hot flashes, mood swings, visual disturbances, and ovarian hyperstimulation. As pharmaceutical science advances, Trans-Clomiphene Citrate represents a refined tool for optimizing hormonal regulation, offering hope for patients seeking targeted reproductive therapies with improved safety profiles compared to non-specific formulations. Ongoing clinical trials continue to define its optimal dosage and long-term efficacy across diverse patient populations.
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