氨甲环酸化学性质熔点:>300°C(lit.)沸点:281.88°C(roughestimate)密度:1.0806(roughestimate)蒸气压:1.72hPaat25℃折射率:1.4186(estimate)储存条件:2-8°C溶解度:Freelysolubleinwaterandinglacialaceticacid,practicallyinsolubleinChemicalbookacetoneandinethanol(96percent).形态:CrystallinePowder酸度系数(pKa):pKa4.3(Uncertain);10.6(Uncertain)颜色:White水溶解性:1g/6mlMerck:14,9569BRN:2207452稳定性:HygroscopicInChIKey:GYDJEQRTZSCIOI-LJGSYFOKSA-N
*The following content is generated by AI and is for reference only.
Tranexamic acid, chemically known as 4-(aminomethyl)cyclohexanecarboxylic acid, is a synthetic derivative of the amino acid lysine. With the molecular formula C8H15NO2 and CAS number 1197-18-8, this white crystalline powder functions primarily as an antifibrinolytic agent in clinical medicine. Its mechanism involves competitively inhibiting the activation of plasminogen to plasmin, thereby preventing the breakdown of blood clots and reducing excessive bleeding. Originally developed for surgical applications and trauma management, it has become a cornerstone therapy for controlling hemorrhage in conditions such as heavy menstrual bleeding, postpartum hemorrhage, and various surgical procedures where significant blood loss is anticipated. Beyond its hemostatic properties, tranexamic acid has gained widespread prominence in dermatology and cosmetic science. In topical formulations, it effectively treats hyperpigmentation disorders, including melasma, post-inflammatory hyperpigmentation, and sunspots. By suppressing melanocyte activity and interfering with the interaction between keratinocytes and melanocytes, often triggered by UV exposure or inflammation, it helps restore a more even skin tone without the harsh side effects associated with some other depigmenting agents. Furthermore, oral administration of low-dose tranexamic acid is increasingly utilized off-label for managing persistent melasma. The compound exhibits high safety profiles when used according to medical guidelines, though caution is advised for patients with a history of thromboembolic disorders due to its potential to increase clotting risk. Available in tablets, injectable solutions, and topical serums, tranexamic acid represents a versatile therapeutic tool bridging critical emergency care and aesthetic medicine. Its ability to stabilize fibrin while modulating pigment production underscores its unique dual utility in modern healthcare, making it an essential component in both hospital settings and professional skincare regimens worldwide.
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