Category:
Prophylactic Biological Products
CAS NO:
87679-37-6
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Trandolapril
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
87679-37-6
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Trandolapril is a potent, long-acting angiotensin-converting enzyme (ACE) inhibitor primarily utilized in the management of hypertension and heart failure. Chemically, its molecular formula is C24H35NO6, and it carries the CAS registry number 107986-02-3. As a prodrug, Trandolapril itself exhibits minimal pharmacological activity; however, upon oral administration, it undergoes rapid hepatic hydrolysis to form its active metabolite, trandolaprilat. This conversion is crucial for its therapeutic efficacy, as trandolaprilat binds selectively to ACE, preventing the conversion of angiotensin I into angiotensin II, a potent vasoconstrictor. By inhibiting this pathway, Trandolapril promotes vasodilation, reduces systemic vascular resistance, and lowers blood pressure without significantly affecting heart rate or causing reflex tachycardia.
The drug is widely prescribed for essential hypertension, often as a monotherapy or in combination with thiazide diuretics to enhance blood pressure control. Furthermore, it plays a significant role in the treatment of left ventricular dysfunction following myocardial infarction and in managing chronic heart failure. Clinical studies have demonstrated that Trandolapril not only improves survival rates in post-infarction patients but also slows the progression of renal disease in hypertensive individuals by reducing intraglomerular pressure. Its once-daily dosing regimen offers excellent patient compliance due to its sustained duration of action and favorable pharmacokinetic profile. Unlike some other ACE inhibitors, Trandolapril has shown a lower incidence of cough, a common side effect associated with bradykinin accumulation, although dry cough remains a potential adverse reaction. Common side effects may include dizziness, headache, fatigue, and hyperkalemia, necessitating regular monitoring of renal function and electrolyte levels during therapy. Contraindications include pregnancy, history of angioedema, and bilateral renal artery stenosis. Overall, Trandolapril represents a cornerstone therapy in cardiovascular medicine, offering robust protection against stroke, myocardial infarction, and heart failure progression through effective renin-angiotensin system modulation.
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