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<h3>Overview</h3>
<p><strong>Trabectedin</strong> (ET-743) is a marine-derived antineoplastic agent produced via fermentation of <em>Pseudoalteromonas haloplanktis</em>. Its molecular formula is C<sub>29</sub>H<sub>35</sub>N<sub>3</sub>O<sub>8</sub>, with CAS No. 162801-21-4.</p>
<h3>Application</h3>
<ul>
<li>Treatment of advanced soft tissue sarcomas refractory to anthracyclines and ifosfamide.</li>
<li>Management of recurrent ovarian cancer in combination with pegylated liposomal doxorubicin.</li>
<li>Research into mechanisms targeting transcription-coupled nucleotide excision repair pathways.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly contraindicated for patients with severe hepatic impairment or neutropenia. Requires specialized handling due to cytotoxicity; store vials at controlled room temperature away from light.</p>