Category:
Prophylactic Biological Products
CAS NO:
119413-54-6
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Topotecan Hydrochloride
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North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
119413-54-6
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Topotecan Hydrochloride is a potent semisynthetic derivative of camptothecin, widely recognized in the pharmaceutical industry as a topoisomerase I inhibitor. Its chemical identity is defined by the molecular formula C23H27NO10·HCl, with a precise molecular weight of approximately 498.9 g/mol for the hydrochloride salt form. The substance is uniquely identified by its CAS Registry Number, 123948-89-8, which serves as a critical reference for regulatory compliance and inventory management globally. Structurally, it features a lactone ring essential for its biological activity, though stability can be influenced by pH levels in solution.
The primary clinical application of Topotecan Hydrochloride lies in oncology, specifically for treating refractory ovarian cancer, small cell lung cancer (SCLC), and cervical cancer. It functions by stabilizing the transient complex formed between DNA and topoisomerase I during replication. This stabilization prevents the religation of DNA strands, leading to double-strand breaks and subsequent apoptosis in rapidly dividing tumor cells. Due to its mechanism of action, it is particularly effective against tumors that have developed resistance to other chemotherapy agents like cisplatin or paclitaxel. Clinically, it is administered intravenously or orally, depending on the specific treatment protocol and patient condition.
Beyond direct therapeutic use, this compound is extensively utilized in research settings. Pharmaceutical laboratories employ it as a standard reference material for bioassays, pharmacokinetic studies, and method validation in quality control processes. Researchers investigate its structure-activity relationships to develop next-generation analogs with improved efficacy and reduced toxicity profiles. Furthermore, it plays a pivotal role in screening new drug combinations designed to overcome multidrug resistance mechanisms in cancer cells. Safety data indicates that while highly effective, the drug requires careful monitoring due to potential side effects such as myelosuppression, nausea, and alopecia. As a cornerstone agent in modern chemotherapy regimens, Topotecan Hydrochloride remains an indispensable tool in the global fight against malignancy, bridging the gap between basic biochemical research and life-saving clinical interventions.
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