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tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate

Category:

Other Intermediates

CAS NO:

1201187-44-1

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Jinan Xinnuo Pharmaceutical Co., Ltd

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Basic Info

CAS Number

1201187-44-1

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Samples Provided

Product Description

Cigna Qingdao is mainly engaged in the intermediates of febuxostatin, ceflothrin, eprazole, flubiprofen, phenalidone, tovaptan, rivaroxaban and Avanafil, terbinafine intermediates, thioacetamide and thiophene and their derivatives.

AI Product Description

*The following content is generated by AI and is for reference only.

tert-Butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate is a specialized organic intermediate widely utilized in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic compounds. With the molecular formula C18H21N3O4S and a molecular weight of approximately 379.44 g/mol, this compound features a fused pyrrolo[2,3-b]pyrazine core substituted with a tosyl group at the 5-position and a tert-butyl carbamate (Boc) protecting group at the 2-position. The presence of these specific functional groups makes it an ideal building block for medicinal chemists engaged in fragment-based drug discovery and lead optimization campaigns. The primary utility of this molecule lies in its role as a protected precursor for synthesizing biologically active nitrogen-rich heterocycles. The Boc group serves as a robust protecting agent for the amine functionality, allowing for selective chemical transformations elsewhere on the scaffold without interference. Conversely, the tosyl moiety acts as a versatile leaving group or a handle for further derivatization, facilitating cross-coupling reactions or nucleophilic substitutions essential for constructing diverse pharmacophores. Researchers frequently employ this compound in the development of kinase inhibitors, anticancer agents, and antiviral drugs where the pyrrolopyrazine motif is known to exhibit potent biological activity. In synthetic workflows, tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate is typically subjected to deprotection conditions to reveal the free amine, which can then be coupled with various electrophiles to generate target libraries. Its stability under standard storage conditions ensures reliable performance in high-throughput screening environments. While specific CAS registry numbers may vary by supplier due to proprietary formulations, the structural identity remains consistent across commercial sources. This reagent represents a critical tool for accelerating the design and synthesis of novel therapeutic candidates, bridging the gap between simple starting materials and complex bioactive molecules. Its unique substitution pattern offers chemists precise control over reaction pathways, enabling the efficient creation of structurally diverse compounds with enhanced potency and selectivity profiles for modern drug development pipelines.