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Prilocaine hydrochloride

Category:

Other Intermediates

CAS NO:

1786-81-8

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Jinan Xinnuo Pharmaceutical Co., Ltd

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Basic Info

CAS Number

1786-81-8

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Samples Provided

Product Description

Cigna Qingdao is mainly engaged in the intermediates of febuxostatin, ceflothrin, eprazole, flubiprofen, phenalidone, tovaptan, rivaroxaban and Avanafil, terbinafine intermediates, thioacetamide and thiophene and their derivatives.

AI Product Description

*The following content is generated by AI and is for reference only.

Prilocaine hydrochloride is a widely utilized local anesthetic belonging to the amide class, chemically known as 2-propylamino-N-(2-methylphenyl)acetamide hydrochloride. Its molecular formula is C13H21ClN2O, and it carries the CAS Registry Number 721-50-6. As a derivative of propionylxylidide, this compound functions by reversibly blocking voltage-gated sodium channels in neuronal membranes, thereby inhibiting the initiation and conduction of nerve impulses. This mechanism effectively produces localized anesthesia without affecting consciousness, making it a cornerstone in various medical and dental procedures. The primary clinical application of Prilocaine hydrochloride involves infiltration anesthesia, nerve blocks, and topical administration for minor surgical interventions. It is particularly favored in dentistry for pulpotomies and soft tissue surgeries due to its rapid onset and intermediate duration of action. A distinct advantage of this agent over lidocaine is its lower potential for systemic toxicity at equivalent doses, attributed to its faster metabolic clearance by hepatic enzymes. However, a unique pharmacological characteristic is its metabolism into o-toluidine, which can occasionally lead to methemoglobinemia, especially in high doses or susceptible individuals such as infants or patients with glucose-6-phosphate dehydrogenase deficiency. Consequently, it is often formulated in combination with epinephrine to prolong the anesthetic effect and reduce systemic absorption, though caution is advised regarding vasoconstrictor sensitivity. Beyond standard medical use, Prilocaine hydrochloride serves as a key ingredient in EMLA cream (a mixture with lidocaine), approved for pre-procedural pain relief during needle insertions, venipuncture, and laser treatments. The hydrochloride salt form ensures high water solubility, facilitating stable aqueous formulations for injection and topical gels. In industrial contexts, it acts as a reference standard in pharmaceutical quality control and analytical chemistry research. Despite the emergence of newer agents, Prilocaine remains a reliable, cost-effective solution for regional anesthesia. Its balanced profile of efficacy, safety, and versatility ensures its continued relevance in modern healthcare settings, provided that dosage limits are strictly observed to mitigate rare but serious adverse reactions like methemoglobinemia.