*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Tacrolimus is a potent <strong>macrolide immunosuppressant</strong> produced via fermentation. It functions by inhibiting calcineurin to prevent T-cell activation. Its molecular formula is C<sub>44</sub>H<sub>75</sub>NO<sub>13</sub>, with CAS number 104987-11-3.</p>
<h3>Application</h3>
<ul>
<li><strong>Organ Transplantation:</strong> Prophylaxis of organ rejection in kidney, liver, and heart transplants.</li>
<li><strong>Dermatology:</strong> Topical treatment for moderate-to-severe atopic dermatitis.</li>
<li><strong>Rheumatology:</strong> Management of steroid-refractory autoimmune conditions.</li>
</ul>
<h3>Precautions</h3>
<p>Strict therapeutic drug monitoring is required due to a narrow therapeutic index. Store in a cool, dry place protected from light. Avoid use in patients with hypersensitivity to macrolides or concomitant nephrotoxic agents.</p>