Category:
Prophylactic Biological Products
CAS NO:
52-01-7
Standard:
USP,EP,
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Basic Info
CAS Number
52-01-7
Pharmacopoeia
USP,EP
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
Usage
：It is used to treat intractable edema associated with elevated aldosterone clinically, therefore more effective for cirrhosis and nephrotic syndrome patients. However it is less effective for congestive heart-failure.
AI Product Description
*The following content is generated by AI and is for reference only.
Spironolactone is a synthetic steroid derivative primarily classified as an aldosterone antagonist, widely utilized in clinical medicine for managing cardiovascular and dermatological conditions. Its chemical identity is defined by the molecular formula C24H32O4S and it is universally recognized by the CAS registry number 52-01-7. Structurally, it belongs to the class of spirostan derivatives, featuring a unique spiroketal ring system that contributes to its specific pharmacological activity. The compound acts competitively by binding to mineralocorticoid receptors in the distal convoluted tubules of the kidney, thereby inhibiting sodium reabsorption and promoting potassium retention. This mechanism effectively reduces fluid volume overload while preserving electrolyte balance, making it a cornerstone therapy for heart failure, hypertension, and edema associated with liver cirrhosis or nephrotic syndrome. Beyond its diuretic properties, Spironolactone exhibits significant anti-androgenic effects, which has led to its widespread off-label and approved use in treating hirsutism, acne, and female pattern hair loss. It is also a critical component in the management of primary hyperaldosteronism. The drug is typically administered orally in tablet form, often at doses ranging from 25 mg to 200 mg daily depending on the severity of the condition. While generally well-tolerated, common side effects include hyperkalemia, menstrual irregularities, gynecomastia in men, and gastrointestinal disturbances. Due to its ability to lower blood pressure and reduce cardiac remodeling, it remains one of the most prescribed medications globally for chronic heart disease. Its versatility extends into veterinary medicine for similar indications in animals. As a cost-effective generic medication, Spironolactone continues to be essential in modern therapeutic regimens, offering dual benefits of volume control and hormonal modulation.
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