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Intermediates&Fine Chemicals

Spironolactone

Category:

Intermediates&Fine Chemicals

CAS NO:

52-01-7

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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INNER MONGOLIA YUANHONG FINE CHEMICAL CO., LTD.

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Basic Info

CAS Number

52-01-7

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Samples Provided

Product Description

Spironolactone 52-01-7

AI Product Description

*The following content is generated by AI and is for reference only.

Spironolactone is a synthetic organic compound widely utilized in clinical medicine as a potassium-sparing diuretic and an aldosterone antagonist. Its molecular formula is C24H32O4S, and it is uniquely identified by the CAS registry number 52-01-7. Structurally, it belongs to the class of steroidal antimineralocorticoids, sharing a steroid backbone that allows it to interact specifically with intracellular mineralocorticoid receptors. Upon administration, spironolactone competes with the natural hormone aldosterone for binding sites within the distal convoluted tubules and collecting ducts of the kidney. By blocking these receptors, it inhibits sodium reabsorption and promotes the excretion of water and sodium while conserving potassium, thereby reducing fluid retention and lowering blood pressure. The primary therapeutic applications of spironolactone include the management of hypertension, often used in combination with other antihypertensive agents, and the treatment of edema associated with congestive heart failure, liver cirrhosis, or nephrotic syndrome. It is also a cornerstone therapy for primary hyperaldosteronism. Beyond its cardiovascular indications, spironolactone has gained significant popularity in dermatology and endocrinology due to its anti-androgenic properties. It effectively treats hirsutism and acne in women by blocking androgen receptors and inhibiting sebum production. Additionally, it serves as a critical component in gender-affirming hormone therapy for transgender women. Despite its efficacy, the drug requires careful monitoring of serum electrolytes, particularly potassium levels, to prevent hyperkalemia. Common side effects may include menstrual irregularities, gynecomastia in men, and gastrointestinal disturbances. Overall, spironolactone remains a versatile and essential pharmaceutical agent in modern medical practice, bridging cardiology, nephrology, and dermatology through its unique dual mechanism of action.