Category:
Prophylactic Biological Products
CAS NO:
51110-01-1
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Somatostatin
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
51110-01-1
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Somatostatin is a potent endogenous peptide hormone that plays a critical regulatory role in the human body, primarily functioning as an inhibitor of growth hormone (GH) secretion. Its molecular formula is C76H108N22O23S4, and it is uniquely identified by the CAS number 38916-34-4. Structurally, this cyclic tetradecapeptide consists of fourteen amino acid residues linked by two disulfide bonds, which are essential for maintaining its biological stability and receptor affinity.
The primary clinical and research application of Somatostatin revolves around its ability to suppress the release of various hormones, including insulin, glucagon, gastrin, and secretin. Due to these broad inhibitory properties, synthetic analogs such as octreotide and lanreotide are widely utilized in medical practice to treat conditions like acromegaly, carcinoid syndrome, and VIPomas. These disorders often involve the overproduction of specific hormones or peptides, leading to severe metabolic and physiological imbalances. By binding to somatostatin receptors (SSTRs), particularly subtypes SSTR2 and SSTR5, the compound effectively downregulates cellular signaling pathways associated with excessive secretion.
Beyond therapeutic uses, Somatostatin serves as a vital tool in biomedical research for studying endocrine regulation, tumor biology, and gastrointestinal physiology. Researchers employ it to investigate the mechanisms of hormone feedback loops and to evaluate the efficacy of new drug candidates targeting neuroendocrine tumors. Furthermore, its role in inhibiting cell proliferation makes it a subject of interest in oncology, where it may help control the growth of certain cancerous tissues. While native Somatostatin has a very short half-life in circulation, limiting its direct clinical utility, its discovery paved the way for the development of long-acting synthetic derivatives that have revolutionized the management of complex endocrine disorders. The molecule remains a cornerstone in both pharmacological interventions and fundamental physiological studies, highlighting its indispensable nature in modern medicine.
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