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<h3>Overview</h3>
<p><strong>Sirolimus</strong> (Rapamycin) is a potent macrolide immunosuppressant produced via microbial fermentation. Its molecular formula is C<sub>51</sub>H<sub>79</sub>NO<sub>13</sub>, and the CAS number is 53123-88-9.</p>
<h3>Application</h3>
<ul>
<li>Prevention of organ transplant rejection in renal transplantation.</li>
<li>Treatment of lymphangioleiomyomatosis (LAM).</li>
<li>Coating for drug-eluting stents to prevent restenosis.</li>
</ul>
<h3>Precautions</h3>
<p>Store at controlled room temperature (20°C–25°C). Avoid direct light. Strictly monitor blood concentrations due to narrow therapeutic index and potential hepatotoxicity.</p>