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CAS NO:
6080-33-7
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Basic Info
CAS Number
6080-33-7
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
please call me ,to know more
AI Product Description
*The following content is generated by AI and is for reference only.
Sinomenine hydrochloride is a well-established pharmaceutical agent derived from the traditional Chinese herb *Sinomenium acutum*, also known as the green snake vine. Chemically, this compound is identified by its molecular formula C19H23NO4·HCl and carries the CAS Registry Number 6570-89-6. It represents the hydrochloride salt form of sinomenine, which enhances its solubility in aqueous solutions compared to the free base, thereby facilitating various pharmaceutical formulations such as tablets, injections, and capsules.
The primary clinical application of Sinomenine hydrochloride lies in the management of inflammatory and autoimmune conditions, most notably rheumatoid arthritis (RA). It functions as an immunomodulator with potent anti-inflammatory properties. Unlike some non-steroidal anti-inflammatory drugs (NSAIDs) that merely mask pain, sinomenine targets the underlying immune response. It works by inhibiting the proliferation of T-lymphocytes and suppressing the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1). This mechanism helps reduce joint swelling, alleviate morning stiffness, and improve overall mobility in patients suffering from chronic joint inflammation.
Beyond rheumatoid arthritis, research has explored its potential efficacy in treating other connective tissue diseases, including systemic lupus erythematosus and allergic reactions. Its ability to stabilize mast cells and inhibit histamine release contributes to its antiallergic effects. The drug is generally considered to have a favorable safety profile when used under medical supervision, although common side effects may include dizziness, nausea, or mild skin rashes. Due to its unique dual action of reducing inflammation and modulating the immune system without causing severe bone marrow suppression, it remains a valuable therapeutic option in both conventional Western medicine and integrative treatment protocols globally. As a standardized synthetic derivative of a natural product, Sinomenine hydrochloride bridges traditional herbal knowledge with modern pharmacological standards, offering a reliable solution for managing chronic inflammatory disorders.
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