Category:
Prophylactic Biological Products
CAS NO:
25126-32-3
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Basic Info
CAS Number
25126-32-3
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Sincalide is a synthetic analog of the endogenous hormone cholecystokinin (CCK-8), specifically designed to mimic the physiological effects of naturally occurring CCK in the human body. Its chemical identity is defined by the molecular formula C39H57N11O12S4 and it is universally recognized by the CAS number 60662-98-8. Structurally, Sincalide consists of an octapeptide chain that retains the essential sulfated tyrosine residue at position 7, which is critical for its high-affinity binding to CCK receptors found primarily in the gallbladder and pancreas.
The primary clinical application of Sincalide lies in hepatobiliary diagnostics, where it serves as a potent stimulant for gallbladder contraction and pancreatic enzyme secretion. In medical practice, it is frequently administered intravenously during cholecystography or nuclear medicine scans to evaluate biliary tract function. By stimulating the release of bile from the gallbladder, Sincalide allows physicians to assess the contractility of the organ and detect potential obstructions or dyskinesia. This diagnostic utility is particularly valuable when imaging results are inconclusive, providing functional data that static images cannot offer. Additionally, its ability to induce pancreatic exocrine secretion makes it useful in assessing pancreatic function, although this use is less common than its role in biliary evaluation.
Pharmacologically, Sincalide acts rapidly upon administration, typically eliciting a response within minutes. It binds selectively to CCK-A receptors on smooth muscle cells, triggering a cascade that leads to muscle contraction. The drug is generally well-tolerated, though transient side effects such as nausea, abdominal discomfort, flushing, or a metallic taste may occur due to its potent hormonal activity. Because it mimics a natural digestive hormone, Sincalide plays a crucial role in modern gastroenterology, bridging the gap between anatomical imaging and physiological assessment. Its stability and specific receptor affinity ensure reliable diagnostic outcomes, making it an indispensable tool for clinicians investigating biliary disorders. As a synthetic peptide, it offers consistent potency compared to crude extracts, ensuring standardized dosing and reproducible clinical results across various patient populations.
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