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Sibutramine hydrochloride 99.0%min supplier Pharmaceutical AP Medicine reducing weight Anti depressi

Category:

Intermediates&Fine Chemicals

CAS NO:

84485-00-7

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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INNER MONGOLIA YUANHONG FINE CHEMICAL CO., LTD.

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CAS Number

84485-00-7

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Samples Provided

Product Description

Sibutramine hydrochloride 99.0%min supplier Pharmaceutical AP Medicine reducing weight Anti depression made in chinaI 84485-00-7

AI Product Description

*The following content is generated by AI and is for reference only.

Sibutramine hydrochloride monohydrate, a pharmaceutical intermediate with a purity of 99.0% minimum, is a synthetic compound historically utilized in weight management and mood regulation therapies. Its chemical structure is defined by the molecular formula C17H26ClN and it is uniquely identified by the CAS Registry Number 83245-45-0 for the anhydrous form, though the monohydrate variant is common in commercial applications. This white crystalline powder functions primarily as a centrally acting appetite suppressant. The primary mechanism of action involves the inhibition of neuronal reuptake of serotonin, norepinephrine, and dopamine. By increasing the levels of these neurotransmitters in the synaptic cleft, Sibutramine hydrochloride enhances satiety signals in the hypothalamus, thereby reducing caloric intake and facilitating weight loss in obese patients. Historically, it was marketed under brand names such as Meridia and Reductil for the treatment of obesity. Additionally, due to its modulation of monoamine levels, it possesses antidepressant properties, although this application is secondary to its metabolic effects. However, it is critical to note that the regulatory status of Sibutramine has changed significantly worldwide. Due to clinical trials revealing an increased risk of serious cardiovascular events, including heart attacks and strokes, major health authorities such as the U.S. FDA and the European Medicines Agency withdrew approval for its use in human medicine between 2010 and 2011. Consequently, while high-purity Sibutramine hydrochloride remains available from chemical suppliers for research purposes, laboratory analysis, or as a reference standard in pharmaceutical quality control, it is strictly prohibited for therapeutic sale or personal consumption in many jurisdictions. Users must adhere to all local regulations regarding controlled substances when handling this material. The product serves as a vital tool for scientific investigation into metabolic pathways and drug safety profiles rather than as a current clinical treatment option.