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Intermediates&Fine Chemicals

Sertraline

Category:

Intermediates&Fine Chemicals

CAS NO:

79617-96-2

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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INNER MONGOLIA YUANHONG FINE CHEMICAL CO., LTD.

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Basic Info

CAS Number

79617-96-2

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Samples Provided

Product Description

Sertraline 79617-96-2

AI Product Description

*The following content is generated by AI and is for reference only.

Sertraline, widely recognized by its generic name and brand names such as Zoloft, is a potent pharmaceutical agent belonging to the class of selective serotonin reuptake inhibitors (SSRIs). Its chemical identity is defined by the molecular formula C17H17Cl2NO and the unique CAS registry number 79617-96-2. Structurally, it features a naphthalene ring system substituted with chlorine atoms and an amine group, which facilitates its specific interaction with neuronal transporters in the central nervous system. The primary clinical application of Sertraline is the treatment of major depressive disorder, offering significant relief from persistent sadness, loss of interest, and related cognitive disturbances. Beyond depression, it serves as a first-line therapy for obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD). By selectively inhibiting the reuptake of serotonin into presynaptic neurons, Sertraline increases the concentration of this neurotransmitter in the synaptic cleft. This mechanism enhances serotonergic transmission, thereby regulating mood, anxiety levels, and impulse control over time. Pharmacokinetically, Sertraline exhibits high oral bioavailability and undergoes extensive hepatic metabolism via cytochrome P450 enzymes, primarily CYP2B6 and CYP3A4, before being excreted. It possesses a relatively long half-life, allowing for once-daily dosing, which improves patient compliance. While generally well-tolerated, common side effects may include nausea, insomnia, dry mouth, sexual dysfunction, and dizziness. Serious adverse reactions, though rare, can involve serotonin syndrome or increased suicidal ideation in young adults during initial treatment phases. Physicians must carefully monitor patients for drug interactions, particularly with other serotonergic agents or monoamine oxidase inhibitors. Due to its efficacy and safety profile, Sertraline remains a cornerstone medication in modern psychiatry, providing hope and stability to millions of individuals worldwide suffering from various mood and anxiety-related conditions.