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CAS NO:
128-57-4
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Basic Info
CAS Number
128-57-4
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Sennoside B is a naturally occurring anthraquinone glycoside primarily isolated from plants of the genus *Cassia*, most notably *Cassia angustifolia* (senna) and *Cassia acutifolia*. Chemically, it belongs to the class of bisanthrones and serves as one of the major active constituents responsible for the therapeutic effects of senna leaves and pods. The molecular formula of Sennoside B is C42H38O20, reflecting its complex structure composed of two anthrone units linked by a carbon-carbon bond and attached to sugar moieties. Its specific CAS Registry Number is 22174-65-8, which uniquely identifies this compound in chemical databases worldwide.
The primary pharmaceutical application of Sennoside B is as an effective stimulant laxative used to treat acute constipation. Upon oral administration, the compound reaches the large intestine largely unchanged due to poor absorption in the upper gastrointestinal tract. There, colonic bacteria hydrolyze the glycosidic bonds, releasing the active aglycone form, rhein anthrone. This metabolite stimulates peristaltic contractions of the intestinal wall and inhibits water and electrolyte reabsorption, thereby softening stool and accelerating bowel evacuation. Consequently, Sennoside B is widely utilized in over-the-counter medications, dietary supplements, and clinical preparations for managing functional constipation, preparing patients for colonoscopies, or relieving occasional irregularity.
Beyond its direct laxative properties, research suggests potential secondary benefits, including mild anti-inflammatory and antioxidant activities, though these are not yet the basis for approved medical indications. While generally safe for short-term use, prolonged consumption may lead to electrolyte imbalances, dependency, or melanosis coli, emphasizing the need for adherence to recommended dosages. As a standardized botanical extract, Sennoside B remains a cornerstone in natural medicine for digestive health, offering a reliable mechanism to restore normal bowel function without the harshness associated with some synthetic alternatives. Its well-documented pharmacokinetics and efficacy profile ensure its continued relevance in global pharmacopeias and consumer health markets.
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