Category:
Prophylactic Biological Products
CAS NO:
84057-95-4
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Ropivacaine
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
84057-95-4
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Ropivacaine is a modern, long-acting local anesthetic belonging to the amide class, widely utilized in clinical anesthesia and pain management. Chemically, it is (S)-ropivacaine hydrochloride, with the molecular formula C17H26N2O·HCl and the CAS number 132194-87-3. Its structure is closely related to bupivacaine but features a propyl group instead of a butyl group at the alpha-position of the nitrogen atom. This subtle structural modification significantly alters its pharmacological profile, resulting in a distinct separation between motor and sensory blockade and a markedly reduced cardiotoxicity compared to racemic bupivacaine.
The primary clinical application of ropivacaine involves providing anesthesia for surgical procedures, labor analgesia, and postoperative pain control. It is frequently administered via epidural, spinal, or peripheral nerve blocks. Due to its favorable safety profile regarding cardiac conduction, it is increasingly preferred for continuous infusions during childbirth and orthopedic surgeries. The drug acts by blocking voltage-gated sodium channels on neuronal membranes, thereby inhibiting the initiation and conduction of nerve impulses. This mechanism effectively prevents pain signals from reaching the central nervous system while preserving motor function to a greater extent than older agents, allowing patients to remain mobile after certain regional anesthesia techniques.
Pharmacokinetically, ropivacaine exhibits rapid absorption and extensive protein binding, primarily to alpha-1-acid glycoprotein. Its onset of action is relatively quick, and the duration of effect can be extended depending on the concentration used and the addition of vasoconstrictors like epinephrine. While generally well-tolerated, systemic toxicity remains a risk if accidental intravascular injection occurs, manifesting as central nervous system excitation followed by depression or cardiovascular collapse. However, the therapeutic index of ropivacaine is wider than that of bupivacaine, making it a safer choice for high-risk populations. As a pure S-enantiomer, it avoids the potential accumulation of the more toxic R-enantiomer found in racemic mixtures. Today, ropivacaine stands as a cornerstone in modern anesthesiology, balancing efficacy with patient safety across diverse medical settings ranging from minor outpatient procedures to major obstetric care.
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