罗库溴铵化学性质熔点:162-1640C比旋光度:D20+18.7°(c=1.03inCHCl3)储存条件:Inertatmosphere,2-8°C溶解度:H2O:soluble100mg/mL,clear,lightyellow形态:PowdertoCrystal颜色:WhitetoChemicalbookYellow水溶解性:H2O:100mg/mL,clear,lightyellowMerck:14,8246稳定性:HygroscopicInChIKey:OYTJKRAYGYRUJK-FMCCZJBLSA-MCAS数据库:119302-91-9(CASDataBaseReference)
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Rocuronium bromide is a widely utilized aminosteroid neuromuscular blocking agent belonging to the class of non-depolarizing muscle relaxants. Its chemical formula is C31H59BrN2O4, and it is uniquely identified by the CAS number 119302-91-9. This compound functions as a competitive antagonist at nicotinic acetylcholine receptors located at the neuromuscular junction. By binding to these receptors without activating them, rocuronium prevents acetylcholine from triggering muscle contraction, thereby inducing flaccid paralysis.
The primary clinical application of rocuronium bromide is in anesthesia to facilitate endotracheal intubation and provide skeletal muscle relaxation during surgical procedures. It is particularly valued for its rapid onset of action, which can be achieved within one minute when administered at appropriate doses, making it a preferred alternative to succinylcholine in many emergency scenarios where rapid sequence induction is required. Unlike depolarizing agents, its effects are not terminated by nerve regeneration but require metabolic clearance or reversal with specific antidotes such as sugammadex, a modified cyclodextrin that encapsulates the drug molecule for rapid elimination.
Beyond general surgery, rocuronium is employed in intensive care units to manage patients requiring mechanical ventilation, ensuring comfort and synchrony with ventilator settings. It is also used in electroconvulsive therapy to prevent musculoskeletal injuries associated with seizure activity. The drug is typically supplied as a sterile, clear, colorless solution for intravenous injection. While generally safe, potential adverse effects include histamine release leading to hypotension or bronchospasm, though these are less common compared to older muscle relaxants. Dosage must be carefully titrated based on patient weight, age, renal function, and concurrent medications to avoid prolonged paralysis. Due to its critical role in maintaining airway patency and surgical conditions, rocuronium bromide remains a cornerstone in modern anesthesiology, balancing efficacy with a manageable safety profile when monitored correctly by trained medical professionals.
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