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Basic Info
CAS Number
478-43-3
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
please call me ,to know more
AI Product Description
*The following content is generated by AI and is for reference only.
Rhein, chemically known as 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid, is a naturally occurring anthraquinone derivative primarily isolated from plants of the genus Rheum, such as Rheum palmatum (rhubarb) and Rheum officinale. Its molecular formula is C15H8O6, and it carries the CAS registry number 478-43-3. This compound exists as a yellow to orange-red crystalline powder that is slightly soluble in water but dissolves readily in alkaline solutions and organic solvents like ethanol and methanol.
Historically, Rhein has been a cornerstone in traditional Chinese medicine and European herbal pharmacopeias for centuries. Its primary application lies in its potent laxative properties. As an active metabolite of sennosides found in Senna leaves, Rhein stimulates peristalsis in the colon, making it effective for treating constipation and preparing patients for bowel examinations. Beyond its gastrointestinal utility, recent scientific research has highlighted its diverse biological activities. Studies suggest that Rhein possesses significant anti-inflammatory, antioxidant, and anti-tumor effects. It has demonstrated the ability to inhibit the growth of various cancer cell lines, including those associated with liver, lung, and breast cancers, by inducing apoptosis and arresting the cell cycle.
Furthermore, Rhein shows promise in managing metabolic disorders. It acts as an inhibitor of protein tyrosine phosphatase 1B (PTP1B), which improves insulin sensitivity and may help regulate blood glucose levels in type 2 diabetes models. In dermatology, its potential to modulate melanin synthesis suggests applications in treating hyperpigmentation. While generally safe at therapeutic doses, excessive consumption can lead to electrolyte imbalances or dependency. Today, Rhein serves not only as a valuable pharmaceutical ingredient in over-the-counter laxatives but also as a critical model compound in biochemistry and drug discovery research, bridging the gap between ancient herbal remedies and modern molecular therapeutics.
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