thyroid hormone receptor β(THR-β)
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<h3>Overview</h3>
<p><strong>Resmetirom</strong> (MGL-319) is a selective thyroid hormone receptor-beta agonist developed for non-alcoholic steatohepatitis. Its core synthesis involves complex heterocyclic coupling. Molecular Formula: <strong>C27H28N6O5S</strong>; CAS No.: <strong>2084350-28-4</strong>.</p>
<h3>Application</h3>
<ul>
<li>Hepatology: Clinical treatment of NASH with moderate to severe fibrosis.</li>
<li>Pharmaceutical R&D: Used as an active pharmaceutical ingredient in metabolic disorder trials.</li>
<li>Diagnostics: Research tool for studying hepatic lipid metabolism pathways.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly contraindicated in patients with uncontrolled hyperthyroidism or severe liver impairment. Store at controlled room temperature (20-25°C) in moisture-proof containers. Handle with appropriate PPE due to potential sensitization risks.</p>