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Other Specialized Reagents

(R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate

Category:

Other Specialized Reagents

CAS NO:

CAS NO.1919868-77-1

Standard:

In-house Standards,

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Hunan HuaTeng Pharmaceutical Co., Ltd.

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Basic Info

CAS Number

CAS NO.1919868-77-1

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Product Description

Huateng Pharmaceutical, a global supplier of pharmaceutical intermediates, offers Larotrectinib intermediates (R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate (CAS No.: 1919868-77-1) for your requirements of R&D, evaluation, pilots and commercial along with supportive technical package required for evaluation.

AI Product Description

*The following content is generated by AI and is for reference only.

(R)-2-(2,5-Difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate is a specialized chiral salt widely utilized in the pharmaceutical and fine chemical industries as a critical intermediate for asymmetric synthesis. Composed of the optically active amine (R)-2-(2,5-difluorophenyl)pyrrolidine paired with (R)-tartaric acid derivative (specifically 2-hydroxysuccinic acid), this compound serves as a versatile building block for constructing complex molecular architectures containing fluorinated heterocycles. The presence of the difluorophenyl moiety imparts unique electronic and lipophilic properties to the molecule, often enhancing metabolic stability and binding affinity in biological targets, which makes it highly valuable in drug discovery programs targeting central nervous system disorders, oncology, and infectious diseases. The primary application of this material lies in its role as a chiral resolving agent or a direct precursor for synthesizing enantiomerically pure compounds. In many synthetic routes, the pyrrolidine ring acts as a rigid scaffold that directs stereochemical outcomes during nucleophilic additions or reductive aminations. By utilizing the (R)-configuration of both components, chemists can ensure high optical purity in the final therapeutic agents, minimizing the production of inactive or potentially toxic enantiomers. This precision is essential for meeting stringent regulatory requirements set by agencies such as the FDA and EMA. Furthermore, the salt form improves the physical stability and solubility profile of the free amine, facilitating easier handling, storage, and purification processes within manufacturing environments. While specific CAS registry numbers for chiral salts may vary depending on the exact stoichiometry and hydration state, this compound is generally recognized under distinct identifiers for its individual components when used in research contexts. It is typically supplied as a white to off-white crystalline powder, requiring storage under inert atmospheres at controlled temperatures to prevent degradation. Researchers employ this reagent in multi-step organic syntheses where stereocontrol is paramount. Its utility extends beyond simple intermediates; it also aids in the development of novel catalysts and ligands for asymmetric transformations. As the demand for fluorinated drugs continues to rise globally, the importance of high-purity chiral precursors like (R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate grows correspondingly, supporting the advancement of next-generation medicines with improved efficacy and safety profiles.