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Other Excipients
CAS NO:
147867-65-0
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Basic Info
CAS Number
147867-65-0
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
YES
Product Description
Application: mPEG-DSPE, CAS NO.: 147867-65-0 is a compound which applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. It is one of the excipients of COVID-19 Vaccines.
AI Product Description
*The following content is generated by AI and is for reference only.
MPEG-DSP is a specialized polymeric surfactant widely utilized in advanced pharmaceutical and biotechnology applications, though it is important to clarify that the term "mPEG-DSPE" likely refers to Methoxy Polyethylene Glycol Distearoyl Phosphatidylethanolamine (often abbreviated as mPEG-DSPE or PEG-DSPE). This molecule represents a critical class of PEGylated lipids essential for modifying nanoparticle surfaces. Its structure consists of a hydrophilic methoxy-polyethylene glycol chain covalently linked to a hydrophobic distearoyl phosphatidylethanolamine backbone. While specific molecular formulas vary slightly depending on the exact degree of polymerization (typically ranging from 2kDa to 5kDa) and the purity of the lipid tails, the general composition involves carbon, hydrogen, nitrogen, oxygen, and phosphorus atoms arranged to create an amphiphilic architecture.
The primary utility of mPEG-DSPE lies in its ability to stabilize liposomal drug delivery systems. When incorporated into lipid bilayers, the long PEG chains extend outward into the aqueous environment, forming a protective hydration layer. This steric barrier significantly reduces opsonization by plasma proteins, thereby extending the circulation half-life of therapeutic carriers within the bloodstream. Consequently, this product is indispensable for creating stealth liposomes designed to target tumors via the enhanced permeability and retention effect or to deliver fragile biologics like siRNA and mRNA vaccines. It prevents aggregation of nanoparticles and improves their biocompatibility, minimizing immune system recognition. Although no single universal CAS number exists due to the polydisperse nature of the PEG component, commercial variants are often cataloged under specific supplier codes or broad ranges associated with PEG-lipids. In summary, mPEG-DSPE serves as a foundational building block in modern nanomedicine, bridging the gap between chemical synthesis and clinical efficacy by ensuring safe, prolonged, and targeted drug delivery across various therapeutic modalities.
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