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CAS NO:
66-97-7
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Basic Info
CAS Number
66-97-7
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
please call me ,to know more
AI Product Description
*The following content is generated by AI and is for reference only.
Psoralen, chemically known as 7H-furo[3,2-g][1]benzopyran-7-one, is a naturally occurring furocoumarin compound widely distributed in plants such as figs, celery, and parsley. Its molecular formula is C₁₁H₆O₃, with a molecular weight of approximately 186.16 g/mol. The substance is identified by the CAS Registry Number 484-05-9. Structurally characterized by a tricyclic system comprising a furan ring fused to a benzene ring and a pyrone moiety, psoralen exhibits unique photochemical properties that have made it invaluable in both medical and research applications.
The primary clinical utility of psoralen lies in its role within PUVA therapy, a treatment modality combining psoralen administration with UVA radiation exposure. In this context, psoralen acts as a photosensitizer; upon absorption of UVA light, it intercalates into DNA and forms covalent cross-links between adjacent thymine bases. This mechanism inhibits rapid cell division, making it highly effective for managing chronic skin conditions such as psoriasis, vitiligo, and cutaneous T-cell lymphoma (mycosis fungoides). By slowing down the proliferation of abnormal skin cells or stimulating repigmentation in depigmented areas, PUVA therapy offers significant therapeutic relief where other treatments may fail.
Beyond dermatology, psoralen serves as an essential tool in molecular biology research. Scientists utilize it to study DNA structure, protein-DNA interactions, and nucleic acid hybridization. Its ability to form reversible or irreversible cross-links under specific light conditions allows researchers to map binding sites on DNA strands and investigate the mechanisms of genetic regulation. Furthermore, due to its phototoxic nature, psoralen is sometimes employed in food safety and preservation studies to assess microbial inactivation via irradiation techniques. However, its use requires strict safety protocols, as uncontrolled exposure can lead to severe phototoxicity, including skin burns and long-term risks of carcinogenesis. Consequently, while psoralen remains a cornerstone in treating specific dermatological disorders and advancing genomic research, its application demands precise dosage control and professional supervision to balance efficacy with patient safety.
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