Category:
Prophylactic Biological Products
CAS NO:
24305-27-9
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Basic Info
CAS Number
24305-27-9
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Protirelin, also known as thyrotropin-releasing hormone (TRH), is a synthetic tripeptide with the molecular formula C14H20N6O5. Its unique chemical structure consists of three amino acids: pyroglutamic acid, histidine, and proline amide, linked by peptide bonds. The substance is identified by the CAS number 1739-08-8. Originally isolated from the hypothalamus, Protirelin has been extensively synthesized for pharmaceutical and research applications due to its ability to stimulate the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary gland.
In clinical diagnostics, Protirelin serves as a gold-standard agent for evaluating pituitary-thyroid axis function. By administering the compound intravenously or intramuscularly, clinicians can assess the integrity of the hypothalamic-pituitary-thyroid feedback loop. A normal response involves a rapid rise in TSH levels within minutes, followed by a secondary peak in thyroid hormones. This test is crucial for distinguishing between primary hypothyroidism, where TSH is already elevated, and central hypothyroidism, where the pituitary fails to respond adequately to stimulation. Additionally, it aids in diagnosing hyperthyroidism and monitoring treatment efficacy in various thyroid disorders.
Beyond endocrine diagnostics, Protirelin has shown promise in neurological research. Studies suggest that TRH analogs may possess neuroprotective properties, potentially aiding recovery after spinal cord injuries or traumatic brain damage by enhancing neurotransmitter release and improving neuronal excitability. While not currently a first-line therapy for these conditions, ongoing investigations continue to explore its potential in treating depression, schizophrenia, and opioid withdrawal symptoms, given its modulatory effects on dopamine and serotonin systems. Despite its limited commercial availability compared to other hormones, Protirelin remains an indispensable tool in both laboratory settings and specialized medical evaluations, offering critical insights into hormonal regulation and neurological health. Its stability and specificity make it a reliable standard for scientific inquiry and clinical assessment worldwide.
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