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CAS NO:
81740-07-0
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Basic Info
CAS Number
81740-07-0
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
please call me ,to know more
AI Product Description
*The following content is generated by AI and is for reference only.
Praeruptorin B is a bioactive triterpenoid saponin isolated primarily from the roots of Peucedanum praeruptorum, a traditional Chinese medicinal herb known as "Baishao." This compound has attracted significant attention in modern pharmacological research due to its diverse therapeutic potentials. The molecular formula of Praeruptorin B is C39H60O12, and it is uniquely identified by the CAS registry number 14784-25-5. Structurally, it belongs to the oleanane-type triterpenoids, characterized by a complex glycosidic linkage that contributes to its solubility and biological activity.
In terms of applications, Praeruptorin B exhibits potent neuroprotective effects, making it a promising candidate for treating ischemic stroke and other neurological disorders. Research indicates that it can effectively reduce cerebral infarction volume and mitigate neuronal apoptosis by modulating key signaling pathways such as PI3K/Akt and Nrf2/HO-1. Furthermore, this compound demonstrates significant anti-inflammatory properties, inhibiting the production of pro-inflammatory cytokines like TNF-α and IL-6, which are crucial in managing chronic inflammatory conditions. Beyond neurology, studies suggest potential anticancer activities, where Praeruptorin B induces cell cycle arrest and apoptosis in various cancer cell lines, including lung and breast cancers, without causing severe toxicity to normal cells.
The compound also shows promise in cardiovascular protection by improving endothelial function and reducing oxidative stress. Due to these multifaceted benefits, Praeruptorin B serves as a valuable lead compound in drug discovery for developing novel therapeutics against stroke, inflammation, and malignancies. Currently, it is widely used in scientific research laboratories as a reference standard for quality control and mechanistic studies rather than as a commercial pharmaceutical product. Its isolation and purification remain critical for validating its efficacy in preclinical models. As research continues, Praeruptorin B stands out as a natural product with high translational potential, bridging traditional medicine knowledge with contemporary biomedical science to address unmet clinical needs in neurodegenerative and oncological diseases.
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