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CAS NO:
518-28-5
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Basic Info
CAS Number
518-28-5
Pharmacopoeia
In-house Standards
Grade
Injection Grade
Is Manufacturer
No
Packaging & Delivery
Packaging Specification
50mg/bag, packed in an aluminum foil bag outside; double-layer PE inside.
Minimum Order Quantity
10g
Delivery Cycle
Inventroy
Product Description
Pharmacology: for disease-resistant poison, this product is cell toxins that inhibits cell division, by inhibiting cell mitosis and amount to antiviral action. Its tinctures can be used for viral infection. Have antipyretic, antiphlogistic, analgesic, broken blood, born muscle effects.
AI Product Description
*The following content is generated by AI and is for reference only.
Podophyllotoxin 98% is a potent naturally occurring lignan primarily isolated from the roots and rhizomes of *Podophyllum* species, such as *Podophyllum peltatum* and *Podophyllum hexandrum*. With a molecular formula of C22H22O8 and a CAS number of 518-28-5, this high-purity compound serves as a critical precursor in the semi-synthetic production of important anticancer agents. Its structural integrity allows for chemical modification to create derivatives like etoposide and teniposide, which are widely used in clinical oncology to treat various malignancies, including testicular cancer, small cell lung cancer, and lymphomas.
The primary mechanism of action involves the inhibition of microtubule polymerization during the M-phase of the cell cycle. By binding to tubulin, Podophyllotoxin prevents the formation of spindle fibers, effectively arresting cell division and inducing apoptosis in rapidly proliferating tumor cells. This cytotoxic property makes it an invaluable tool in pharmacological research and drug development laboratories focused on novel chemotherapy strategies. The 98% purity specification ensures minimal impurities, providing researchers with consistent data for in vitro assays, structure-activity relationship studies, and quality control processes in pharmaceutical manufacturing.
Beyond its direct therapeutic applications, this compound is extensively utilized as a reference standard for analytical chemistry, aiding in the validation of HPLC and mass spectrometry techniques. It is also employed in toxicological studies to evaluate cellular responses to antimitotic agents. While highly effective against cancer cells, its narrow therapeutic index necessitates careful handling and precise dosing in both experimental and clinical settings. As a key intermediate in the synthesis of life-saving medications, Podophyllotoxin 98% remains indispensable in the global fight against cancer. Researchers must adhere to strict safety protocols when working with this substance due to its potential toxicity and irritant properties. Continued investigation into its derivatives aims to enhance efficacy while reducing systemic side effects, ensuring that this natural product continues to play a pivotal role in modern medicine and biotechnology advancements worldwide.
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