Appearance:
white or similar to white crystalline powder, odorless, soluble in dimethylformamide, slightly soluble in ethanol, water and chloroform. M.P. is 198-204℃
*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p><strong>Phthalylsulphathiazole</strong> is a bacteriostatic sulfonamide derivative synthesized via acetylation of sulphathiazole with phthalic anhydride. It serves as an enteric-coated prodrug for localized intestinal action. Molecular Formula: C<sub>14</sub>H<sub>12</sub>N<sub>4</sub>O<sub>4</sub>S; CAS No.: 80-56-2.</p>
<h3>Application</h3>
<ul>
<li>Treatment of bacillary dysentery and amoebiasis.</li>
<li>Management of non-specific ulcerative colitis.</li>
<li>Preoperative bowel preparation protocols.</li>
</ul>
<h3>Precautions</h3>
<p>Contraindicated in patients with sulfa hypersensitivity or severe renal impairment. Store in cool, dry conditions away from light to maintain chemical stability and prevent hydrolysis.</p>