Product Description
please call me ,to know more
AI Product Description
*The following content is generated by AI and is for reference only.
Phloridzin, also known as phloretin glucoside, is a naturally occurring dihydrochalcone glycoside primarily found in the bark and leaves of apple trees (Malus domestica) and other members of the Rosaceae family. Its chemical identity is defined by the molecular formula C21H24O10 and the CAS registry number 53-97-0. Structurally, it consists of the aglycone phloretin linked to a glucose molecule at the C-6 position, which significantly influences its solubility and biological activity compared to its non-glycosylated counterpart.
In the realm of scientific research, Phloridzin has garnered substantial attention for its potent inhibitory effects on sodium-dependent glucose transporters (SGLTs), particularly SGLT1 and SGLT2. This mechanism makes it a valuable tool for studying glucose metabolism and renal physiology. By blocking the reabsorption of glucose in the proximal tubules of the kidney, it mimics the action of modern anti-diabetic drugs, leading to increased urinary glucose excretion. Consequently, it serves as a critical reference compound in the development of therapies for type 2 diabetes and obesity. Beyond metabolic applications, Phloridzin exhibits notable antioxidant and anti-inflammatory properties, contributing to its investigation in neuroprotection and skin health formulations.
Commercially and industrially, this compound is utilized in the production of dietary supplements aimed at blood sugar regulation and weight management. It is also employed in cosmetic science for its potential to inhibit melanogenesis, offering benefits for skin brightening and pigmentation control. While generally regarded as safe in controlled doses, its bioavailability can be limited due to extensive metabolism in the gut and liver. Researchers continue to explore prodrug strategies to enhance its therapeutic efficacy. Overall, Phloridzin remains a pivotal molecule bridging traditional herbal medicine with modern pharmacological innovation, offering promising avenues for treating metabolic disorders and supporting overall cellular health through its unique dual-action profile on glucose transport and oxidative stress reduction.