Category:
Prophylactic Biological Products
CAS NO:
5534-95-2
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Pentagastrin
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
5534-95-2
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Pentagastrin is a synthetic pentapeptide that serves as a crucial diagnostic tool in clinical medicine, primarily designed to mimic the physiological effects of endogenous gastrin. Its chemical structure consists of five amino acids arranged in the sequence H-Pro-Lys-Trp-Met-Asp-NH2. The molecular formula for Pentagastrin is C27H36N6O5S, and it carries the CAS registry number 1048-39-5. This specific peptide is chemically stable and retains high biological activity, making it an essential reagent for evaluating gastric secretory function.
The primary application of Pentagastrin lies in the stimulation of gastric acid secretion. It acts as a potent agonist for cholecystokinin B (CCK-B) receptors located on parietal cells within the stomach lining. Upon administration, usually via intravenous injection, it triggers these cells to release hydrochloric acid into the gastric lumen. This mechanism allows clinicians to perform the "Pentagastrin test," which is instrumental in diagnosing conditions such as Zollinger-Ellison syndrome, a rare disorder characterized by excessive acid production due to gastrin-secreting tumors. By measuring the peak acid output following stimulation, physicians can distinguish between hypersecretory states and normal gastric physiology.
Beyond its diagnostic role, Pentagastrin has been utilized in research settings to study the pathophysiology of peptic ulcer disease and gastroesophageal reflux. While endoscopic procedures have largely replaced some traditional functional tests, Pentagastrin remains a gold standard reference compound in pharmacological studies regarding gastric mucosal integrity and acid regulation. It is typically supplied as a sterile lyophilized powder or solution for laboratory use. Researchers must handle this substance with care, adhering to safety protocols, as it induces significant physiological responses. Its specificity for CCK-B receptors ensures minimal cross-reactivity with other systems, providing reliable data for both clinical diagnostics and academic investigations into gastrointestinal disorders. Consequently, Pentagastrin continues to be a vital asset in the armamentarium of gastroenterologists and biomedical researchers worldwide.
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