储存条件:2-8°C溶解度:H2O:soluble30mg/mL,clear形态:powder颜色:whitetobeige水溶解性:H2O:30mg/mL,clear稳定性:Stablefor1yearassupplied.SolutionsindistilledwatermaybestoreChemicalbookdat-20°forupto31month.InChIKey:AEZRDYKQLPDYEH-YTCXBBKHNA-NSMILES:C(C1=CNC2NC(N)=NC(=O)C1=2)CC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1.[NaH].O|&1:20,r|
*The following content is generated by AI and is for reference only.
Pemetrexed Disodium Heptahydrate is the sodium salt form of pemetrexed, a potent multi-targeted antifolate chemotherapeutic agent widely utilized in oncology. With the Chemical Abstracts Service (CAS) registry number 178506-43-9, this compound serves as the active pharmaceutical ingredient (API) for the treatment of malignant pleural mesothelioma and non-small cell lung cancer (NSCLC). Its molecular formula is C20H20N7Na2O6S·7H2O, reflecting its complex structure which includes a glutamate moiety, a pyrimidine ring, and a pteridine ring system essential for its biological activity. The heptahydrate form indicates the presence of seven water molecules within the crystal lattice, influencing its solubility, stability, and handling characteristics during pharmaceutical manufacturing.
Functionally, Pemetrexed Disodium Heptahydrate operates by inhibiting multiple enzymes critical for nucleotide synthesis, specifically thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase. By blocking these pathways, the drug effectively disrupts DNA synthesis and repair, leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. Unlike traditional single-agent antifolates, its broad-spectrum inhibition allows it to target tumors with high efficacy while maintaining a manageable toxicity profile when administered with appropriate vitamin supplementation, typically folic acid and vitamin B12, to mitigate hematologic and gastrointestinal side effects.
In clinical practice, this medication is primarily indicated for patients with unresectable malignant pleural mesothelioma and locally advanced or metastatic NSCLC. It is often employed as a first-line monotherapy or in combination with platinum-based agents such as cisplatin or carboplatin. The disodium salt formulation ensures adequate aqueous solubility for intravenous infusion, facilitating precise dosing and rapid distribution throughout the body. As a cornerstone in modern chemotherapy regimens, Pemetrexed Disodium Heptahydrate represents a significant advancement in targeting specific metabolic vulnerabilities within tumor cells, offering improved survival outcomes and quality of life for patients suffering from these aggressive malignancies. Ongoing research continues to explore its potential in other solid tumors and novel combination therapies.
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