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Other Specialized Reagents

palovarotene

Category:

Other Specialized Reagents

CAS NO:

410528-02-8

Standard:

ChP,USP,BP,EP,JP,In-house Standards,IP,Ph. Int,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Jiangsu Magic Biotechnology Co., Ltd

Years

Show Room

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Basic Info

CAS Number

410528-02-8

Pharmacopoeia

ChP,USP,BP,EP,JP,In-house Standards,IP,Ph. Int

Grade

Pharmaceutical Grade

Is Manufacturer

YES

Packaging & Delivery

Minimum Order Quantity

100g

Delivery Cycle

Product Description

体内研究Palovarotenesuppressespost-traumaticchondrogenesisandosteogenesisandmitigatedtrauma-inducedectopicboneformation.Palovaroteneinhibitssubcutaneousandintramuscularheterotopicossification(HO)inmice.Palovaroteneisgivenorallyfor14daysat1mg/kg/daystartingonpost-operativeday(POD)1orPOD-5,andHOamount,wounddehiscenceandrelatedprocessesaremonitoredforupto84dayspostinjury.Comparedtovehicle-controlanimals,PalovarotenesignificantlydecreasesHOby50to60%regardlesChemicalbooksofwhenthetreatmentstartedandifinfectionispresent.Startingfromday1ofinjury,halfoftheAcvr1cR206H/+micearetreatedwithPalovarotenebydailygavagefor14daysandtheotherhalfreceivedvehicleascontrol.AnalysisbymCTand3Dimagereconstructionatday14showsthatlargeHOtissuemasseshaveformedinthetargetedlegofAcvr1cR206H/+mutantmicereceivingvehicle,butHOformationisgreatlydiminishedinPalovarotene-treatedcompanionsbymorethan80%basedonbonevolume/totalvolumequan