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Intermediates&Fine Chemicals

Oxolinic acid

Category:

Intermediates&Fine Chemicals

CAS NO:

14698-29-4

Standard:

In-house Standards,

Price Range:

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North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Basic Info

CAS Number

14698-29-4

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Samples Provided

Product Description

Oxolinic acid 14698-29-4

AI Product Description

*The following content is generated by AI and is for reference only.

Oxolinic acid is a synthetic quinolone antibiotic belonging to the first generation of this class of antimicrobial agents. With the Chemical Abstracts Service (CAS) registry number 14698-29-0, its molecular formula is C₁₄H₁₂N₂O₃ and it possesses a molecular weight of approximately 256.26 g/mol. This compound functions primarily by inhibiting bacterial DNA gyrase, an enzyme essential for DNA replication, transcription, and repair, thereby exerting a bactericidal effect against susceptible Gram-negative organisms. Historically, Oxolinic acid has been widely utilized in veterinary medicine rather than human therapeutics due to its efficacy profile and safety margin in animals. It is commonly prescribed to treat various infections caused by sensitive bacteria, including urinary tract infections, respiratory tract disorders, and gastrointestinal ailments in livestock such as poultry, swine, and fish. In aquaculture, it plays a significant role in managing diseases like vibriosis and enteric redmouth disease, contributing to the health and productivity of farmed aquatic species. Its ability to be administered orally makes it a convenient option for treating large groups of animals efficiently. Despite its historical importance, the use of Oxolinic acid has faced regulatory scrutiny in many regions due to concerns regarding the development of bacterial resistance and potential environmental accumulation. Consequently, its application is often restricted or banned in certain countries to preserve the efficacy of other antibiotics and mitigate ecological risks. Nevertheless, it remains a critical tool in specific veterinary contexts where alternative treatments are ineffective or unavailable. The chemical structure features a naphthyridine core substituted with fluorine and carboxylic acid groups, which are characteristic of early-generation fluoroquinolones. While newer generations of quinolones have largely superseded it in human medicine, Oxolinic acid continues to serve as a vital component in global animal health strategies when used responsibly under strict veterinary supervision. Understanding its pharmacokinetics and resistance patterns remains essential for optimizing therapeutic outcomes while minimizing adverse impacts on public health and the environment.