Category:
Antiparasitic
CAS NO:
16773-42-5
Standard:
In-house Standards,IP,
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Basic Info
CAS Number
16773-42-5
Pharmacopoeia
In-house Standards,IP
Grade
Pharmaceutical Grade
Is Manufacturer
YES
Samples Provided
YES
Product Description
Primarily used to treat infections caused by protozoans & bacteria. It is used to treat amoebiasis, chlamydiosis, giardia infection, trichomonas infection, vaginal, urinary tract, intestinal and post-operative infections.
AI Product Description
*The following content is generated by AI and is for reference only.
Ornidazole is a synthetic nitroimidazole antibiotic and antiprotozoal agent widely utilized in clinical settings to treat various anaerobic bacterial infections and protozoal diseases. Chemically, it shares structural similarities with metronidazole but possesses a distinct 2-methyl-5-nitroimidazole core substituted with an oxazolidine ring, which enhances its pharmacokinetic profile and reduces the incidence of certain side effects. The molecular formula of Ornidazole is C7H10N4O3, and it is uniquely identified by the CAS registry number 69668-56-0. This compound appears as a white or almost white crystalline powder, practically insoluble in water but soluble in dilute acids and organic solvents like ethanol.
The primary therapeutic applications of Ornidazole involve the management of infections caused by sensitive anaerobic bacteria, such as Bacteroides species, Clostridium species, and Fusobacterium. It is highly effective against protozoan parasites, including Entamoeba histolytica (causing amoebiasis), Giardia lamblia (responsible for giardiasis), and Trichomonas vaginalis (the causative agent of trichomoniasis). Due to its high tissue penetration and long half-life, Ornidazole allows for convenient dosing regimens, often requiring fewer doses compared to older nitroimidazoles, thereby improving patient compliance. It is commonly prescribed for gastrointestinal disorders, gynecological infections, and prophylactic treatment prior to surgical procedures involving the oral cavity or gastrointestinal tract to prevent postoperative anaerobic infections.
Mechanistically, Ornidazole enters microbial cells where its nitro group is reduced by intracellular electron transport proteins, generating toxic free radicals that damage DNA and inhibit nucleic acid synthesis, ultimately leading to cell death. While generally well-tolerated, common adverse reactions may include gastrointestinal disturbances, dizziness, or metallic taste. Patients are advised to avoid alcohol consumption during therapy to prevent disulfiram-like reactions. As a versatile antimicrobial, Ornidazole remains a cornerstone in the global treatment arsenal against anaerobic and protozoal pathogens, offering a safe and effective alternative for diverse clinical scenarios.
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