Name:6-Ethylchenodeoxycholic acid
Alias:6-ECDCA;
INT-747;
UNII-0462Z4S4OZ;
6alpha-Ethyl-chenodeoxycholic acid;
Obeticholic acid;
CAS No.:459789-99-2
Molecular formula:C26H44O4
Molecular weight:420.62500
Exact mass:420.32400
PSA:77.76000
LogP:5.11400
*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Obeticholic Acid is a second-generation <strong>FXR agonist</strong> synthesized via chemical modification of chenodeoxycholic acid. It serves as a critical intermediate for treating cholestatic liver diseases. The compound features the molecular formula <strong>C24H36O5</strong> and CAS number <strong>46708-71-6</strong>.</p>
<h3>Application</h3>
<ul>
<li><strong>Pharmaceutical Manufacturing:</strong> Primary API for NASH and primary biliary cholangitis (PBC) therapies.</li>
<li><strong>Clinical Research:</strong> Used in Phase III trials to evaluate efficacy on fibrosis regression.</li>
<li><strong>Quality Control:</strong> Standard reference material for analytical method validation in GMP labs.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly contraindicated in patients with complete biliary obstruction or severe hepatic impairment. Store in sealed containers at 2-8°C away from light. Handle with appropriate PPE due to potential hepatotoxicity risks during synthesis.</p>