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Intermediates&Fine Chemicals

Nystatin ,Nysfungin

Category:

Intermediates&Fine Chemicals

CAS NO:

1400-61-9

Standard:

,In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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INNER MONGOLIA YUANHONG FINE CHEMICAL CO., LTD.

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Basic Info

CAS Number

1400-61-9

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Samples Provided

Product Description

Nystatin ,Nysfungin 1400-61-9

AI Product Description

*The following content is generated by AI and is for reference only.

Nystatin, also known commercially as Nysfungin, is a potent polyene antifungal antibiotic produced by the bacterium *Streptomyces noursei*. Its molecular formula is C47H75NO17, and it is identified by the CAS Registry Number 1400-61-9. This macrocyclic compound features a large lactone ring with multiple conjugated double bonds, which is critical for its mechanism of action against fungal cells. Nystatin works primarily by binding to ergosterol, an essential sterol found in the cell membranes of fungi but absent in mammalian cells. Upon binding, it creates transmembrane channels that disrupt membrane integrity, leading to the leakage of intracellular ions and small molecules, ultimately causing cell death. Due to this selective toxicity, it is highly effective against various Candida species, including *Candida albicans*, and other susceptible yeasts. Clinically, Nystatin is widely utilized for the prevention and treatment of superficial fungal infections, particularly those affecting the skin, mouth, and gastrointestinal tract. It is commonly formulated as topical creams, ointments, powders, and oral suspensions. A notable advantage of Nystatin is its lack of systemic absorption when administered orally or topically, making it safe for use in infants, pregnant women, and immunocompromised patients who are prone to thrush or diaper rash. Unlike some azole antifungals, resistance to Nystatin remains relatively rare, though cross-resistance can occur among polyenes. While not effective against dermatophytes or deep systemic mycoses due to poor absorption, it remains a first-line therapy for mucocutaneous candidiasis. The product serves as a cornerstone in antifungal pharmacotherapy, offering a reliable solution for managing common yeast infections without significant systemic side effects. Its stability and safety profile ensure its continued relevance in both human medicine and veterinary applications, where it is used to treat similar fungal conditions in animals.