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Intermediates&Fine Chemicals

Nicardipine hydrochloride

Category:

Intermediates&Fine Chemicals

CAS NO:

54527-84-3

Standard:

In-house Standards,

Price Range:

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North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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Basic Info

CAS Number

54527-84-3

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Samples Provided

Product Description

Nicardipine hydrochloride 54527-84-3

AI Product Description

*The following content is generated by AI and is for reference only.

Nicardipine hydrochloride is a widely utilized pharmaceutical agent belonging to the dihydropyridine class of calcium channel blockers. Its chemical formula is C26H30N2O8·HCl, and it is universally recognized by the CAS Registry Number 54219-76-8. This compound functions primarily as a potent vasodilator, exerting its therapeutic effects by selectively inhibiting the influx of calcium ions through L-type voltage-gated calcium channels in vascular smooth muscle cells. By blocking these channels, Nicardipine hydrochloride prevents the contraction of blood vessels, leading to significant relaxation and subsequent reduction in peripheral vascular resistance. The primary clinical application of this medication is the management of severe hypertension, particularly in acute settings such as hypertensive emergencies where rapid but controlled blood pressure reduction is critical. It is frequently administered intravenously in hospital environments for immediate effect or orally for the maintenance treatment of chronic high blood pressure. Additionally, it is sometimes employed in the management of angina pectoris due to its ability to improve myocardial oxygen supply by dilating coronary arteries while reducing cardiac afterload. The drug exhibits high selectivity for vascular smooth muscle over cardiac muscle, which minimizes adverse cardiac side effects like negative inotropy, although reflex tachycardia can occasionally occur. Pharmacokinetically, Nicardipine hydrochloride undergoes extensive first-pass metabolism in the liver via the cytochrome P450 enzyme system, specifically CYP3A4. Consequently, its bioavailability varies significantly between oral and parenteral routes. Common side effects include flushing, headache, dizziness, and peripheral edema, resulting from its vasodilatory properties. Due to its short half-life when given intravenously, continuous monitoring is often required during infusion therapy. Overall, Nicardipine hydrochloride remains a cornerstone in cardiovascular pharmacotherapy, offering a reliable mechanism for controlling blood pressure and managing ischemic heart conditions with a favorable safety profile when used under appropriate medical supervision.