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Other Specialized Reagents

NH2-PEG2-CH2COOH

Category:

Other Specialized Reagents

CAS NO:

CAS NO.134978-97-5

Standard:

In-house Standards,

Price Range:

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Main Sales Markets:

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Hunan HuaTeng Pharmaceutical Co., Ltd.

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Basic Info

CAS Number

CAS NO.134978-97-5

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Product Description

Huateng Pharma, a professional pharmaceutical intermediate supplier, provides Semaglutide intermediate 2-(2-(2-Aminoethoxy)ethoxy)acetic acid (CAS No. 134978-97-5) with high quality and purity, which is a medication for the treatment of type 2 diabetes.

AI Product Description

*The following content is generated by AI and is for reference only.

NH2-PEG2-CH2COOH, chemically known as Amino-PEG2-Carboxylic acid or 2-(Amino)-polyethylene glycol-2-acetic acid, is a versatile heterobifunctional PEGylation reagent widely utilized in bioconjugation and chemical biology applications. Its molecular formula is C8H17NO5, with a precise molecular weight of approximately 203.23 g/mol. While specific commercial suppliers may assign varying catalog numbers, this compound does not possess a single universally unique CAS registry number due to its nature as a generic structural motif often sold by multiple vendors under different trade names; however, it belongs to the broader class of amino-terminated polyethylene glycols modified with carboxyl groups. The molecule features a primary amine group at one terminus and a carboxylic acid group at the other, separated by two ethylene glycol units (PEG2). This specific architecture allows for highly efficient coupling reactions: the amine can react with activated esters, aldehydes, or NHS-esters on target biomolecules, while the carboxyl group can be activated using carbodiimide chemistry (e.g., EDC/NHS) to conjugate with amines on proteins, peptides, or nanoparticles. The short PEG spacer provides optimal flexibility and solubility, enhancing the biocompatibility of the resulting conjugate without excessively increasing steric hindrance. Primary applications include the modification of therapeutic proteins to improve their pharmacokinetic profiles, reduce immunogenicity, and extend serum half-life. It is also extensively employed in the synthesis of drug delivery systems, such as antibody-drug conjugates (ADCs), where controlled attachment of cytotoxic agents is critical. Furthermore, researchers utilize NH2-PEG2-CH2COOH to functionalize surfaces for biosensors or to create self-assembled monolayers in nanotechnology. Its water solubility and stability make it an ideal linker for creating stable covalent bonds between diverse biological entities and synthetic materials, facilitating advancements in targeted therapy and diagnostic imaging.