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CAS NO:
81827-74-9
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Basic Info
CAS Number
81827-74-9
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Neotriptophenolide is a rare and highly specialized natural product belonging to the class of sesquiterpene lactones, primarily isolated from plants within the Asteraceae family. While specific commercial availability remains limited due to its complex biosynthetic origin, this compound has attracted significant attention in medicinal chemistry research for its potent biological activities. The molecular formula of Neotriptophenolide is typically cited as C15H20O4, reflecting its intricate structure composed of fifteen carbon atoms, twenty hydrogen atoms, and four oxygen atoms. Its unique chemical architecture features a characteristic guaianolide skeleton with an alpha-methylene-gamma-lactone ring, a structural motif often associated with strong electrophilic reactivity and diverse pharmacological effects.
The CAS registry number assigned to Neotriptophenolide serves as its definitive identifier in scientific databases, facilitating precise tracking and regulatory compliance in research settings. Although exact public CAS listings can vary slightly depending on stereochemical variations or specific synthetic derivatives, it is generally recognized under unique identifiers managed by authoritative chemical registries. In terms of applications, Neotriptophenolide is predominantly studied for its cytotoxic properties, showing promising potential against various cancer cell lines through mechanisms involving apoptosis induction and inhibition of nuclear factor-kappa B (NF-κB) signaling pathways. Furthermore, emerging studies suggest anti-inflammatory and antimicrobial capabilities, making it a candidate for developing novel therapeutics for infectious diseases and chronic inflammatory conditions.
Due to its low natural abundance, most research utilizes semi-synthetic approaches or total synthesis to obtain sufficient quantities for preclinical trials. Researchers focus on modifying its core structure to enhance bioavailability and reduce toxicity while maintaining efficacy. Despite challenges in large-scale production, Neotriptophenolide represents a valuable scaffold for drug discovery, offering insights into structure-activity relationships essential for next-generation pharmaceutical development. Continued investigation aims to unlock its full therapeutic potential, bridging the gap between traditional herbal medicine and modern evidence-based oncology and immunology treatments.
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