Category:
Prophylactic Biological Products
CAS NO:
78115-72-7
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Nafarelin Acetate
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
78115-72-7
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Nafarelin Acetate is a potent synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH), widely utilized in clinical settings for the management of hormone-dependent conditions. Its molecular formula is C54H72N16O13S2, and it carries the CAS registry number 80437-92-3. This compound functions as a GnRH agonist, characterized by its high affinity for pituitary GnRH receptors. Upon initial administration, Nafarelin stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), causing a transient surge in sex steroids. However, with continuous therapeutic dosing, this persistent stimulation leads to receptor downregulation and desensitization, ultimately suppressing the hypothalamic-pituitary-gonadal axis. This mechanism results in a profound reduction of estrogen and testosterone levels, creating a reversible medical menopause or hypogonadal state.
The primary clinical application of Nafarelin Acetate is the treatment of endometriosis, where it effectively alleviates pelvic pain and reduces the size of endometrial implants by inhibiting estrogen production. It is also indicated for central precocious puberty in children, helping to delay premature sexual development by halting the early activation of the pubertal axis. Additionally, it serves as a valuable tool in assisted reproductive technologies to prevent premature ovulation during controlled ovarian hyperstimulation protocols. Administered primarily via intranasal spray, the drug offers a non-invasive delivery method that ensures consistent bioavailability. While generally well-tolerated, common side effects include hot flashes, headaches, vaginal dryness, and mood changes, reflecting the induced hypoestrogenic state. Despite these potential adverse events, Nafarelin Acetate remains a cornerstone therapy for gynecological disorders requiring precise hormonal modulation. Its specific pharmacological profile allows clinicians to manage complex reproductive conditions with efficacy, offering patients relief from chronic symptoms while preserving fertility potential upon cessation of treatment. The acetate salt form enhances stability and solubility, ensuring optimal performance in nasal formulations.
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