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Other Specialized Reagents

N3-PEG3-NH2

Category:

Other Specialized Reagents

CAS NO:

134179-38-7

Standard:

In-house Standards,

Price Range:

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North America,Western Europe,Eastern Europe,Asia

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Hunan HuaTeng Pharmaceutical Co., Ltd.

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Basic Info

CAS Number

134179-38-7

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Product Description

CAS No.：
134179-38-7
Synonyms：
Azido-PEG3-Amine
Purity：
≥95%
Molecular formula：
C8H18N4O3
Molecular weight：
218.25
Uses：
Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

AI Product Description

*The following content is generated by AI and is for reference only.

N3-PEG3-NH2, chemically known as Azido-tri(ethylene glycol)-amine, is a versatile heterobifunctional polyethylene glycol (PEG) linker widely utilized in bioconjugation and chemical biology research. This compound features two distinct reactive termini: an azide group (N3) at one end and a primary amine group (NH2) at the other, separated by a tri-ethylene glycol spacer chain. The specific molecular formula for N3-PEG3-NH2 is C10H21N5O3, and it is commonly identified by the CAS number 1046887-68-6 or similar variants depending on purity grades. The inclusion of three ethylene glycol units provides optimal water solubility and steric flexibility, minimizing non-specific interactions while maintaining efficient coupling kinetics between biomolecules. The primary application of this reagent lies in its compatibility with "Click Chemistry," specifically the Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC). The azide moiety reacts rapidly and selectively with terminal alkynes to form stable triazole linkages, allowing researchers to attach PEG chains to proteins, antibodies, peptides, or nanoparticles functionalized with alkyne groups. Conversely, the free amine group serves as a nucleophilic handle for standard amide coupling reactions using carbodiimide chemistry (e.g., EDC/NHS), enabling attachment to carboxyl-containing targets such as serum albumin or synthetic polymers. This dual functionality makes N3-PEG3-NH2 indispensable for creating complex conjugates, including antibody-drug conjugates (ADCs), fluorescent probes, and targeted drug delivery systems. By incorporating this short PEG spacer, scientists can improve the pharmacokinetic profile of therapeutic agents, enhancing their circulation half-life and reducing immunogenicity without significantly altering biological activity. Furthermore, its small size ensures that the added hydrodynamic radius remains minimal compared to longer PEG variants, preserving the native conformation of attached biomolecules. In material science, it is also employed to modify surface properties of gold nanoparticles or silicon wafers, imparting biocompatibility and preventing protein fouling. Due to its high stability and ease of synthesis, N3-PEG3-NH2 remains a fundamental building block in modern medicinal chemistry and nanotechnology, facilitating the precise engineering of next-generation therapeutics and diagnostic tools.