Product Description
lower price 90.0%~96.0% of C14H10N4O5 Yellowish-orange to orange crystalline powder Dantrolene sodium 24868-20-0
AI Product Description
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Dantrolene Sodium, chemically known as 5-nitro-2-furazanecarboxylic acid (3-chlorophenyl)hydrazide sodium salt, is a specialized pharmaceutical agent with the molecular formula C14H10ClN4NaO5. Its corresponding CAS Registry Number is 28693-67-8. This compound typically presents as a yellowish-orange to orange crystalline powder, characterized by high purity levels often ranging between 90.0% and 96.0%. As a direct-acting skeletal muscle relaxant, Dantrolene Sodium functions uniquely by inhibiting calcium release from the sarcoplasmic reticulum within muscle cells. This mechanism prevents the interaction between actin and myosin filaments, thereby reducing muscle contraction strength without affecting central nervous system transmission or neuromuscular junctions.
The primary clinical application of Dantrolene Sodium is the management and prevention of malignant hyperthermia, a life-threatening condition triggered by volatile anesthetic agents or succinylcholine during surgery. In this critical scenario, rapid administration can halt the uncontrolled rise in body temperature and metabolic rate associated with severe muscle rigidity. Beyond acute anesthesia complications, it serves as a therapeutic option for chronic spasticity resulting from neurological disorders such as spinal cord injuries, stroke, multiple sclerosis, or cerebral palsy. By alleviating muscle stiffness and spasms, it significantly improves patient mobility and quality of life.
Pharmaceutical-grade Dantrolene Sodium is widely utilized in hospital settings, emergency departments, and research laboratories. Its stability and efficacy make it a standard inventory item for anesthesiologists worldwide. While effective, its use requires careful monitoring due to potential hepatotoxicity and other side effects like drowsiness or weakness. The availability of high-purity batches ensures reliable performance in both emergency rescue protocols and long-term therapeutic regimens. Consequently, Dantrolene Sodium remains an indispensable tool in modern medicine for managing severe muscle hyperactivity and preventing fatal metabolic crises.