Category:
Prophylactic Biological Products
CAS NO:
2044-56-6
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Lithium Dodecyl Sulfate
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
2044-56-6
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Lithium Dodecyl Sulfate (LDS), chemically known as lithium dodecyl sulfate, is an essential anionic surfactant widely utilized in analytical chemistry and biochemistry laboratories. Its molecular formula is C12H25LiO4S, reflecting a long hydrophobic dodecyl chain attached to a hydrophilic sulfate group coordinated with a lithium cation. The substance is identified by the CAS Registry Number 2078-36-8. This compound plays a pivotal role as a key reagent in SDS-PAGE (Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis) techniques, specifically for the separation of proteins based on their molecular weight. Unlike sodium dodecyl sulfate, LDS offers distinct advantages in certain applications due to its unique solubility properties and compatibility with downstream mass spectrometry analyses.
In protein electrophoresis, LDS effectively denatures proteins by binding to their polypeptide chains, imparting a uniform negative charge proportional to their mass. This ensures that migration through the polyacrylamide gel matrix depends primarily on size rather than intrinsic charge or shape. Lithium salts are particularly favored when subsequent analysis requires minimal interference from metal ions, as lithium does not precipitate easily with common buffers or detergents used in sample preparation. Furthermore, LDS is highly soluble in water and various organic solvents, making it versatile for diverse buffer systems. It is commonly employed in conjunction with reducing agents like beta-mercaptoethanol or dithiothreitol to break disulfide bonds, ensuring complete unfolding of protein structures. Beyond standard electrophoresis, this surfactant finds application in cell lysis protocols, membrane protein extraction, and the formulation of specialized cleaning agents where mild yet effective detergent action is required. Its ability to stabilize protein complexes while maintaining separation efficiency makes it an indispensable tool for researchers studying proteomics, enzyme kinetics, and molecular biology. High-purity grades are available to meet stringent laboratory standards, ensuring reproducible results across experiments. As a critical component in modern biotechnological workflows, Lithium Dodecyl Sulfate continues to support advancements in understanding cellular mechanisms and developing diagnostic assays.
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