Category:
Prophylactic Biological Products
CAS NO:
851199-59-2
Standard:
ChP,USP,
Indications:
Mechanism of Action: Linaclotide and its active metabolite bind to and activate the guanylate cyclase-C (GC-C) receptor on the luminal surface of the intestinal epithelium. This activation leads to increased concentrations of cyclic guanosine monophosphate (cGMP), which subsequently leads to the activation of the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel, resulting in increased chloride and bicarbonate secretion into the intestine. This increased fluid secretion helps soften stool and facilitate bowel movements.
Pharmacokinetics:
Form: Linaclotide API is typically available as a white to off-white powder.