Category:
Prophylactic Biological Products
CAS NO:
74381-53-6
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Basic Info
CAS Number
74381-53-6
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Leuprolide is a synthetic decapeptide analogue of gonadotropin-releasing hormone (GnRH), widely utilized in clinical settings for the treatment of hormone-dependent conditions. With the chemical formula C59H83N17O12S and CAS registry number 59745-06-7, this compound acts as a potent agonist that initially stimulates, followed by profound downregulation of pituitary GnRH receptors. This unique mechanism leads to a significant suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, ultimately reducing sex steroid production from the gonads.
The primary therapeutic applications of Leuprolide include the management of advanced prostate cancer, endometriosis, central precocious puberty, and uterine leiomyomata. In oncology, it serves as a critical component of androgen deprivation therapy for metastatic prostate cancer, effectively inhibiting tumor growth driven by testosterone. For gynecological disorders, it alleviates symptoms associated with endometriosis, such as pelvic pain and heavy menstrual bleeding, often used prior to surgical procedures to shrink fibroids. Additionally, it delays the onset of puberty in children diagnosed with central precocious puberty, allowing for normal psychosocial development during childhood.
Administered via intramuscular or subcutaneous injection in various depot formulations ranging from monthly to yearly durations, Leuprolide offers sustained release profiles that enhance patient compliance. While generally well-tolerated, common side effects mirror those induced by hypogonadism, including hot flashes, decreased libido, and bone density loss. Despite these potential adverse reactions, its efficacy in controlling hormone-sensitive diseases has established Leuprolide as a cornerstone medication in modern endocrinology and oncology. Ongoing research continues to explore novel delivery systems and combination therapies to further optimize its clinical utility while minimizing long-term metabolic risks. As a standard-of-care agent, it remains indispensable for managing complex hormonal imbalances across diverse patient populations globally.
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