*The following content is generated by AI and is for reference only.
<h3>Overview</h3>
<p>Lee011 succinate is the sodium succinate salt of abemaciclib, a potent CDK4/6 inhibitor. Manufactured via pharmaceutical synthesis and crystallization, its molecular formula is <strong>C<sub>28</sub>H<sub>35</sub>N<sub>7</sub>O<sub>2</sub>·C<sub>4</sub>H<sub>4</sub>NaO<sub>4</sub></strong> (CAS: 2094296-66-7).</p>
<h3>Application</h3>
<ul>
<li><strong>Oncology:</strong> Treatment of HR-positive, HER2-negative advanced breast cancer.</li>
<li><strong>Clinical Trials:</strong> Investigated for solid tumors with specific kinase mutations.</li>
<li><strong>Pharmaceutical Manufacturing:</strong> Active Pharmaceutical Ingredient (API) for tablet formulations.</li>
</ul>
<h3>Precautions</h3>
<p>Strictly contraindicated in severe hepatic impairment. Requires storage at controlled room temperature (20°C to 25°C) in dry conditions. Handling mandates PPE to prevent inhalation or dermal exposure during processing.</p>