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CAS NO:
32854-75-4
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Basic Info
CAS Number
32854-75-4
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
Lappaconitine is a potent diterpenoid alkaloid primarily isolated from the roots of Aconitum species, notably Aconitum carmichaelii and Aconitum kusnezoffii, which are widely utilized in traditional Chinese and Siberian medicine. With the chemical formula C31H43NO5 and CAS Registry Number 2780-65-2, this compound features a complex polycyclic structure characteristic of the aconitane skeleton, contributing to its high biological activity. It serves as a valuable pharmacological agent, particularly renowned for its significant antiarrhythmic properties. Research indicates that lappaconitine acts by blocking sodium channels, thereby stabilizing cardiac membranes and reducing abnormal electrical conduction without causing the severe toxicity often associated with other aconitine derivatives when administered at therapeutic doses.
Beyond cardiology, studies have explored its potential analgesic effects, suggesting it may be useful in managing chronic pain conditions by modulating neuronal excitability. Its mechanism involves inhibiting voltage-gated sodium channels, similar to local anesthetics but with distinct selectivity profiles. In scientific research, lappaconitine is frequently employed as a standard reference compound or tool molecule to investigate ion channel dynamics and membrane physiology. While it holds promise for developing safer cardiovascular drugs, strict safety protocols are essential due to the narrow therapeutic index inherent to many aconitum alkaloids. The compound is generally supplied as a hydrochloride salt to enhance solubility for experimental applications. Pharmaceutical development continues to focus on optimizing delivery systems to maximize efficacy while minimizing off-target effects. As a natural product derivative, it bridges traditional herbal knowledge with modern molecular pharmacology, offering insights into treating life-threatening arrhythmias and neuropathic pain. Researchers must handle it with extreme caution, ensuring compliance with all regulatory guidelines regarding controlled substances and toxicological testing before any clinical application is considered.
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