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Prophylactic Biological Products
CAS NO:
53308-83-1
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L-NMMA Acetate
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FENHE CHEMICAL CO., LIMITED
5
Years
Basic Info
CAS Number
53308-83-1
Pharmacopoeia
In-house Standards
Grade
Pharmaceutical Grade
Is Manufacturer
No
Product Description
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AI Product Description
*The following content is generated by AI and is for reference only.
L-NMMA Acetate, chemically known as Nω-Nitro-L-arginine methyl ester dihydrochloride acetate salt, is a potent and selective inhibitor of nitric oxide synthase (NOS) enzymes. With the CAS number 147632-09-1, this compound serves as a critical research tool in biomedical sciences, particularly for investigating the physiological and pathological roles of nitric oxide (NO). Its molecular formula is typically represented as C₈H₁₇N₃O₂·CH₃COOH, though exact stoichiometry may vary depending on hydration states and specific salt forms used in commercial preparations.
The primary application of L-NMMA Acetate lies in its ability to reversibly block the conversion of L-arginine to NO by inhibiting both constitutive and inducible isoforms of NOS. This inhibition makes it an invaluable reagent for studying vascular tone regulation, blood pressure control, and immune responses mediated by NO signaling pathways. Researchers frequently utilize this compound in vitro and in vivo models to elucidate mechanisms underlying hypertension, septic shock, and inflammatory diseases. By suppressing NO production, scientists can observe downstream effects on smooth muscle relaxation, platelet aggregation, and neuronal transmission.
Beyond basic research, L-NMMA Acetate aids in drug discovery efforts targeting NOS-related disorders. It helps validate potential therapeutic strategies that aim to modulate NO levels without causing systemic toxicity. The acetate salt form enhances solubility in aqueous buffers compared to free base or hydrochloride variants, facilitating easier handling in laboratory settings. However, users must exercise caution due to its biological activity; improper dosing can lead to unintended physiological consequences in experimental subjects.
Despite its utility, L-NMMA Acetate is strictly for research purposes only and not approved for human or veterinary use. Regulatory bodies classify it as a controlled chemical substance requiring appropriate licensing for acquisition and storage. Laboratories employing this reagent must adhere to strict safety protocols, including proper personal protective equipment and waste disposal procedures. As our understanding of NO biology expands, L-NMMA Acetate remains a cornerstone compound for advancing knowledge in cardiovascular physiology, immunology, and neuroscience. Future studies may further refine its specificity or develop analogs with improved pharmacological profiles, but for now, it continues to be indispensable in exploring the complex world of nitric oxide signaling systems across diverse biological contexts.
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