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Ketotifen fumarate

Category:

Intermediates&Fine Chemicals

CAS NO:

34580-14-8

Standard:

,In-house Standards,

Price Range:

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Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

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INNER MONGOLIA YUANHONG FINE CHEMICAL CO., LTD.

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Basic Info

CAS Number

34580-14-8

Pharmacopoeia

In-house Standards

Grade

Pharmaceutical Grade

Is Manufacturer

Samples Provided

Product Description

Ketotifen fumarate 34580-14-8

AI Product Description

*The following content is generated by AI and is for reference only.

Ketotifen fumarate is a widely utilized pharmaceutical compound belonging to the class of piperidine derivatives, primarily recognized for its dual mechanism of action as both an antihistamine and a mast cell stabilizer. Chemically identified by the CAS number 29825-71-8, this substance possesses the molecular formula C20H21NO4S·C4H4O4, reflecting its structure as the fumarate salt of ketotifen. The molecule features a distinctive tricyclic core that facilitates potent binding to histamine H1 receptors while simultaneously inhibiting the release of inflammatory mediators such as histamine, leukotrienes, and prostaglandins from mast cells. The primary clinical application of ketotifen fumarate lies in the management of allergic conditions, particularly allergic conjunctivitis and asthma prophylaxis. As an ophthalmic solution, it effectively alleviates symptoms like itching, redness, and watering associated with seasonal or perennial allergic eye diseases. In respiratory therapy, it serves as a preventive agent for bronchial asthma, helping to reduce the frequency and severity of attacks by stabilizing airway mast cells. Although not indicated for acute asthma exacerbations, long-term use can significantly improve quality of life for patients suffering from chronic allergic inflammation. Beyond human medicine, ketotifen has found utility in veterinary practice for managing similar allergic disorders in dogs and cats. Its ability to cross the blood-brain barrier occasionally results in sedation as a side effect, which some clinicians leverage for its mild anxiolytic properties, though this requires careful dosage monitoring. The drug is generally well-tolerated, with common adverse effects including dry mouth, dizziness, and transient weight gain. Due to its efficacy in preventing allergic reactions rather than treating them acutely, patient education regarding consistent usage is crucial for optimal therapeutic outcomes. Ketotifen fumarate remains a cornerstone in allergy pharmacotherapy, offering a safe and effective option for long-term disease management across diverse populations.